Antileshmanial Activities of Synthetic Substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones

作者：Khan Saadia Razi; Ghouri Nida; Karim Aneela; Naz Farzana; Fakhri Muhammad Imran; Perveen Shahnaz; Khan Khalid Mohammed^*; Taha Muhammad; Choudhary Muhammad Iqbal

来源：Journal of the Chemical Society of Pakistan, 2015, 37(5): 980-985.

• Substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-one
• Antileishmail activities

Substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones 1-27 were evaluated for their activity against Leishmania major. Compounds 1-27 demonstrated in vitro antileishmanial activities with IC50 values between 28.9-69.05 mu M, as compared to standard drug pentamidine (IC50 = 5.09 +/- 0.04 mu M). Compounds 12 (IC50 = 28.90 +/- 1.10 mu M), 24 (IC50 = 31.4 +/- 2.15 mu M), 13 (IC50 = 35.0 +/- 3.18 mu M), 16 (IC50 = 35.0 +/- 3.13 mu M), and 25 (IC50 = 35.0 +/- 3.18 mu M) displayed signifiant antileishmanial activities. Whereas, compounds 8-10, 15, 19, and 26 with IC50 values of 62.2 +/- 3.36, 57.8 +/- 2.30, 57.72 +/- 5.02, 56.18 +/- 4.40, 57.85 +/- 2.25, 69.05 +/- 6.20, 54.8 +/- 1.50, and 57.8 +/- 2.30 mu M showed a moderate antileishmanial activities.

• 出版日期2015-10