A dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy

作者：Huang, Lin; Liu, Jia; Gao, Fan; Cheng, Qian; Lu, Bo^*; Zheng, Hua; Xu, Haixing; Xu, Peihu; Zhang, Xianzheng; Zeng, Xuan^*

来源：Journal of Materials Chemistry B, 2018, 6(28): 4618-4629.

DOI：10.1039/c8tb00989a

• PHOTODYNAMIC THERAPY
• MULTIDRUG-RESISTANCE
• CONTROLLED-RELEASE
• PH STIMULI
• ENZYME
• CHEMOTHERAPY
• MICROENVIRONMENT
• ENHANCEMENT
• PLATFORM

In this study, a novel drug delivery system (HMSNs-SS-HA) based on hollow mesoporous silica nanoparticles (HMSNs) was developed for delivering anticancer drugs (e.g., doxorubicin (DOX)) to targeted tumour cells by using disulfide bonds as redox-sensitive linkers and hyaluronic acid (HA) molecules as both capping and targeting agents. Well-dispersed HMSNs were synthesized with a dimension of around 100 nm. Detailed physical characterization further demonstrated that HMSNs-SS-HA has been successfully constructed. The in vitro drug release experiments displayed the enzyme and redox dual-responsive and sustained drug release properties of DOX loaded HMSNs-SS-HA. Additionally, a series of biological evaluations indicated that these DOX loaded HMSNs-SS-HA could accurately target murine mammary carcinoma (4T1) cells to induce cell apoptosis in vitro and suppress tumour growth in vivo. These results demonstrated that DOX loaded HMSNs-SS-HA was suitable as a potential and efficient drug delivery nanosystem for cancer therapy.

• 出版日期2018-7-28
• 单位武汉大学; 武汉理工大学; 华中科技大学