Near-infrared luminescence and RNA cleavage ability of lanthanide Schiff base complexes derived from N,N'-bis (3-methoxysalicylidene)ethylene-1,2-diamine ligands

作者：Kaczmarek Anna M^*; Porebski Piotr W Alvarez; Mortier Tineke; Lynen Frederic; Van Deun Rik; Van Hecke Kristof^*

来源：Journal of Inorganic Biochemistry, 2016, 163: 194-205.

DOI：10.1016/j.jinorgbio.2016.07.017

• Schiff base
• Lanthanide
• Luminescence
• Crystal structure
• RNA cleavage

A complete series of lanthanide Schiff base salen-type complexes were prepared with trivalent lanthanide ions (Ln(3+)) and the N,N'-bis-(3-methoxysalicylidene)ethylene-1,2-diamine ligand (Ln(3+) = La3+, Ce3+, Pr3+, Nd3+, Sm3+, Eu3+, Gd3+, Tb3+, Dy3+, Ho3+, Er3+, Tm3+, Yb3+ Lu3+). Three unique crystal structures of La3+ and Pr3+ N,N'-bis-(3-methoxysalicylidene)ethylene-1,2-diamine complexes, with the Le(3+) complex prepared in two different synthetic approaches, are reported, namely a dimeric [La(H2L)(NO3)(3)](2) (H2L = N,N'-bis-(3methoxysalicylidene)ethylene-1,2-diamine) complex, an asymmetric two-centered [La-2(H2L)(2)(NO3)(6)]) complex and a discrete mononuclear [Pr(H2L)(NO3)(2)(H2O)(2)] complex. For Nd3+ and Sm3+, an isotypic mononuclear [Nd(H2L)(NO3)(3)] and ID polymeric [Sm(H2L)(NO3)(3)(MeOH)]n structure was obtained, respectively. The whole series of complexes was tested for their ability to cleave the 20-mer RNA oligonucleotide 5'-AGC-GAU-AAG-AUU-CAU-AUA-UC-3'. Additionally three complexes (Ln(3+) = Nd3+, Sm3+, Ho3+) were tested for the cleavage of the 12-mer RNA oligonucleotide 5'-GCA-CCC-UGU-CAG-3'. A detailed luminescence study was additionally carried out and revealed that the Eu3+ complex emitted bright red light upon excitation at both 285.8 nm and 394.4 nm. The Nd3+, Er3+, and Yb3+ complexes showed strong emission in the near-infrared region after excitation at 380 nm.

• 出版日期2016-10