Neurophysiological assessment of the sedative and analgesic effects of a constant rate infusion of dexmedetomidine in the dog

作者：van Oostrom Hugo^*; Doornenbal Arie; Schot Arend; Stienen Peter J; Hellebrekers Ludo J

来源：Veterinary Journal, 2011, 190(3): 338-344.

DOI：10.1016/j.tvjl.2010.11.025

• Dexmedetomidine
• Dog
• Evoked potential
• Sedation
• Analgesia

The sedative and analgesic effects of continuous rate infusion (CRI) of dexmedetomidine (DEX) were investigated in Beagle dogs (n = 8) using auditory and somatosensory evoked potentials (AEPs and SEPs) recorded before, during and after a CRI of saline or DEX (1.0, 3.0, 5.0 mu g/kg bolus, followed by 1.0, 3.0, 5.0 mu g/kg/h CRI, respectively).
The results showed a significant reduction in AEP at doses of 1.0 mu g/kg/h and above and a significant reduction of the SEP at doses of 3.0 and 5.0 mu g/kg/h. Neither the AEP nor the SEP was further reduced at 5.0 mu g/kg/h when compared to 3.0 mu g/kg/h, although a slower return towards baseline values was observed at 5.0 mu g/kg/h. The mean plasma levels (+/- SEM) of DEX during infusion were 0.533 +/- 0.053 ng/mL for the 1.0 mu g/kg/h dose, 1.869 +/- 0.063 ng/mL for the 3.0 mu g/kg/h dose and 4.017 +/- 0.385 for the 5.0 mu g/kg/dose. It was concluded that in adult dogs, a CRI of DEX had a sedative and analgesic effect that could be described quantitatively using neurophysiological parameters. Sedation was achieved at lower plasma levels than required for analgesia, and DEX had a longer (but not larger) effect with infusion rates above 3.0 mu g/kg/h.

• 出版日期2011-12