Antidepressant-like activity of icariin mediated by group I mGluRs in prenatally stressed offspring

作者：Zhang, Xiaoxiao; Sun, Hongli; Su, Qian; Lin, Tianwei; Zhang, Huiping; Zhang, Junli; Dang, Shaokang; Zhu, Zhongliang^*

来源：Brain & Development, 2017, 39(7): 593-600.

DOI：10.1016/j.braindev.2017.03.021

• Depression
• Icariin
• Prenatal restraint stress
• Group I mGluR receptors
• EAAT2

Objective: The present study was performed to identify antidepressant-like activity of icariin in prenatally stressed male rats.
Methods: The effects of icariin on PRS-induced depression were examined using sucrose preference test (SPT) and forced swimming test (FST) in male offspring, and measuring protein and mRNA expressions of group I mGluRs receptors and EAAT2 via western blotting and quantitative real-time PCR assays.
Results: The results indicated that prenatal restraint stress (PRS) resulted in several behavioral anomalies. Treatment with icariin relieved the elevated protein and mRNA levels of group I mGluR receptors as well as the diminished protein and mRNA levels of EAAT2 in the PRS male offspring.
Conclusions: Collectivity, the data support that icariin ameliorates PRS-induced depressive-like behavior via regulating expression of mGluR1, mGluR5 and EAAT2 in the hippocampus.

• 出版日期2017-8
• 单位西北大学; 西安交通大学