Antiplasmodial indole alkaloids from Leuconotis griffithii

作者：Nugroho Alfarius E; Hirasawa Yusuke; Piow Wong Chin; Kaneda Toshio; Hadi A Hamid A; Shirota Osamu; Ekasari Wiwied; Widyawaruyanti Aty; Morita Hiroshi^*

来源：Journal of Natural Medicines, 2012, 66(2): 350-353.

DOI：10.1007/s11418-011-0574-2

• Leucoridine A N-oxide
• Indole alkaloids
• Leuconotis griffithii
• Antiplasmodial activity

A new indole alkaloid, leucoridine A N-oxide (1), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii. Its structure was elucidated by various spectroscopic means such as NMR and MS, and also by chemical means. Antiplasmodial activity against Plasmodium falciparum 3D7 of indole alkaloids isolated from L. griffithii was investigated.

• 出版日期2012-4