Alarmins and immunity

作者：Yang De; Han Zhen; Oppenheim Joost J

来源：Immunological Reviews, 2017, 280(1): 41-56.

DOI：10.1111/imr.12577

<jats:title>Summary</jats:title><jats:p>More than a decade has passed since the conceptualization of the “alarmin” hypothesis. The alarmin family has been expanding in terms of both number and the concept. It has recently become clear that alarmins play important roles as initiators and participants in a diverse range of physiological and pathophysiological processes such as host defense, regulation of gene expression, cellular homeostasis, wound healing, inflammation, allergy, autoimmunity, and oncogenesis. Here, we provide a general view on the participation of alarmins in the induction of innate and adaptive immune responses, as well as their contribution to tumor immunity.</jats:p>

• 出版日期2017-11