MR Assessment of Acute Pathologic Process after Myocardial Infarction in a Permanent Ligation Mouse Model: Role of Magnetic Nanoparticle-Contrasted MRI

作者：Park Cheongsoo; Park Eun Hye; Kang Jongeun; Zaheer Javeria; Lee Hee Gu; Lee Chul Ho; Chang Kiyuk^*; Hong Kwan Soo^*

来源：Contrast Media and Molecular Imaging, 2017, 2017: UNSP 2870802.

DOI：10.1155/2017/2870802

We evaluated the relationship between myocardial infarct size and inflammatory response using cardiac magnetic resonance imaging (CMR) in an acute myocardial infarction (AMI) mouse model. Myocardial infarction (MI) was induced in 14 mice by permanent ligation of the left anterior descending artery. Late gadolinium enhancement (LGE), manganese-enhanced MRI (MEMRI), and magnetofluorescent nanoparticle MRI (MNP-MRI) were performed 1, 2, and 3 days after MI, respectively. The size of the enhanced lesion was quantitatively determined usingOtsu's thresholdingmethod in area-based and sector-based approaches and was compared statistically. Linear correlation between the enhanced lesion sizes was evaluated by Pearson's correlation coefficients. Differences were compared using Bland-Altman analysis. The size of the inflammatory area determined by MNP-MRI (57.1 +/- 10.1%) was significantly larger than that of the infarct area measured by LGE (40.8 +/- 11.7%,P < 0.0001) and MEMRI (44.1 +/- 14.9%,P < 0.0001). There were significant correlations between the sizes of the infarct and inflammatory lesions (MNP-MRI versus LGE: r = 0.3418, P = 0.0099; MNP-MRI versus MEMRI: r = 0.4764, P = 0.0002). MNP-MRI provides information about inflammatory responses in a mousemodel of AMI. Thus, MNP-MRI associated with LGE and MEMRI may play an important role in monitoring the disease progression in MI.

• 出版日期2017