A New Method of Reducing 2-Mercapto-Substituted 1,3,4-Oxadizoles: Synthesis of Acylhydrazine Derivatives

作者：Zareef Muhammad; Iqbal Rashid; Zaidi Javid Hussain^*; Arfan Muhammad; Ali Muhammad; Khan Khalid M

来源：Letters in Organic Chemistry, 2010, 7(5): 411-414.

DOI：10.2174/157017810791514670

• Acylhydrazine derivatives
• benzenediazasulfonamides
• 1,3,4-oxadiazole
• sodium acytoxyborohydride

A new method has been developed for the synthesis of acylhydrazines 5a-g by the reduction of unsymmetrical 1,3,4-oxadiazoles 4a-g by using sodium borohydride/acetic acid combination. Later on, acylhydrazines 5a-g were converted to their corresponding sulfonamide derivatives 6a-d.

• 出版日期2010-7