A novel three-component method for the synthesis of spiro[chromeno [4',3':4,5] pyrimido[1,2-b] indazole-7,3'-indoline]-2',6(9H)-dione

作者：Jadhav Amol Maruti; Balwe Sandip Gangadhar; Lim Kwon Taek; Jeong Yeon Tae^*

来源：Tetrahedron, 2017, 73(19): 2806-2813.

DOI：10.1016/j.tet.2017.03.084

• Spiro[chromeno[4 ',3 ':4,5] pyrimido[1,2-b] indazole-7,3 '-indoline]-2 ',6(9 H)-dione derivatives
• Michael reaction
• One-pot synthesis
• Multi-component reaction

A green, efficient, and rapid procedure for the synthesis of novel spiro[chromeno[4',3':4,5] pyrimido[1,2-b]indazole-7,3'-indoline]-2',6(9 H)-dione derivatives has been developed by one-pot condensation of 4-hydroxy-2H-chromen-2-one, isatin, and 1H-indazole-3-amine, in the presence of acetic acid in EtOH. This method has the advantages of operational simplicity, and high yield of products via a simple experimental and work-up procedure as compared to the conventional methods. The reaction mechanism and substrate scope of this novel reaction is briefly discussed.

• 出版日期2017-5-11