Amelioration of the DSS-induced colitis in mice by pretreatment with 4,4 '-diaponeurosporene-producing Bacillus subtilis

作者：Jing, Yuchao; Liu, Haofei; Xu, Wenwen; Yang, Qian^*

来源：Experimental and Therapeutic Medicine, 2017, 14(6): 6069-6073.

DOI：10.3892/etm.2017.5282

• colitis
• 4,4 '-diaponeurosporene
• Bacillus subtilis
• probiotics

Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Current IBD treatments have poor tolerability and insufficient therapeutic efficacy, thus, alternative therapeutic approaches are required. Recently, a number of dietary supplements have emerged as promising interventions. In the present study oral administration of a carotenoid (4,4'-diaponeurosporene) producing Bacillus subtilis markedly ameliorated dextran sulfate sodium salt-induced mouse colitis, as demonstrated by a reduction in weight loss and the severity of bleeding, which indicated that 4,4'-diaponeurosporene may have beneficial effects on treatments for colitis. This preliminary study indicated that 4,4'-diaponeurosporene may function synergistically with probiotics to provide a novel and effective strategy to prevent colitis.

• 出版日期2017-12
• 单位南京农业大学