Autophagy process is associated with anti-neoplastic function

作者：Wang Chong; Wang Yachen; McNutt Michael A; Zhu Wei Guo^*

来源：Acta Biochimica et Biophysica Sinica, 2011, 43(6): 425-432.

DOI：10.1093/abbs/gmr028

• autophagy
• cancer
• Beclin 1
• FoxO
• mTOR
• p53

Autophagy is a highly conserved process of cellular degradation, which is present in yeast, plants, and mammals. Under normal physiological conditions, autophagy acts to maintain cellular homeostasis and regulate the turnover of organelles. In response to cellular stresses, autophagy prevents the accumulation of impaired proteins and organelles, which serves to inhibit carcinogenesis. On this basis, it is widely accepted that most tumor suppressors, such as beclin 1 associated proteins, forkhead box class O (FoxO) family proteins, multiple mammalian target of Rapamycin (mTOR) inactivators, and nuclear p53 play a role in inducing autophagy. Here, we focus on how the process of autophagy is associated with anti-neoplastic function.

• 出版日期2011-6
• 单位北京大学