A new sesquiterpenoid quinone with cytotoxicity from Abelmoschus sagittifolius

作者：Chen, De-Li; Zhang, Xiao-Po; Ma, Guo-Xu; Wu, Hai-Feng; Yang, Jun-Shan; Xu, Xu-Dong^*

来源：Natural Product Research, 2016, 30(5): 565-569.

DOI：10.1080/14786419.2015.1033624

• Abelmoschus sagittifolius
• sesquiterpenoid
• cytotoxicity

A new sesquiterpenoid quinone, Acyl hibiscone B (1), together with five known compounds, (R)-lasiodiplodin (2), (R)-de-O-methyllasiodiplodin, (3) dibutyl phthalate (4), (R)-9-phenylnonan-2-ol (5) and hibiscone B (6), was obtained from the stem tuber of Abelmoschus sagittifolius. The structure of compound 1 was elucidated by analysing its H-1 and C-13 NMR, H-1-H-1 COSY, HSQC, HMBC, NOESY and HR-ESI-MS values. Compound 1 showed significant cytotoxicity against Hela and HepG-2 human cancer cell lines.

• 出版日期2016
• 单位北京协和医学院; 河北医科大学; 中国医学科学院北京协和医院; 海南医学院