Zwitterionic glutathione monoethyl ester as a new capping ligand for ultrasmall gold nanoparticles

作者：Knittel Luiza L; Schuck Peter; Ackerson Christopher J; Sousa Alioscka A

来源：RSC Advances, 2016, 6(52): 46350-46355.

DOI：10.1039/c6ra07777c

The natural tripeptide glutathione has become a popular choice for passivating the surface of gold nanoparticles (NPs) intended for in vivo applications. Here we investigate a zwitterionic derivative of glutathione - glutathione monoethyl ester - as a new capping ligand for ultrasmall NPs. The new zwitterionic particles (AuGSH(zwt)) were colloidally stable in biological media and resistant against binding from serum proteins. AuGSH(zwt), but not glutathione-coated particles, could be successfully functionalized with strep-tag II for binding specifically to target streptactin in the presence of serum proteins. Taken together, these results place AuGSH(zwt) as a promising choice for attaining simultaneous in vivo renal clearance and targeted delivery via incorporation of functional peptides.

• 出版日期2016
• 单位NIH