A Novel and Facile Synthetic Approach for Tasigna

作者：Pan, Xiaoyan; Lu, Wen; Li, Pengfei; Wang, Fang; Wang, Chen; Hu, Zhigang; Zhang, Jie^*

来源：Medicinal Chemistry, 2012, 8(5): 985-989.

DOI：10.2174/157340612802084207

• Tasigna
• Bcr-Abl kinase inhibitor
• Facile synthesis
• Cu-catalyzed N-arylation
• Condensation

A simple and practical synthetic approach for tasigna was described here in six steps with high yield (40%). All of the intermediates and final target compound were isolated cleanly in high yield without a need for chromatographic purification. Significantly, the facile synthetic route proposed in this work has the characteristics of mild synthetic conditions, inexpensive reagents, high yield and simple operation.

• 出版日期2012-9
• 单位西安交通大学