FGF-2 Stimulates Periodontal Regeneration: Results of a Multi-center Randomized Clinical Trial

作者：Kitamura M; Akamatsu M; Machigashira M; Hara Y; Sakagami R; Hirofuji T; Hamachi T; Maeda K; Yokota M; Kido J; Nagata T; Kurihara H; Takashiba S; Sibutani T; Fukuda M; Noguchi T; Yamazaki K; Yoshie H; Ioroi K; Arai T; Nakagawa T; Ito K; Oda S; Izumi Y; Ogata Y; Yamada S; Shimauchi H; Kunimatsu K; Kawanami M; Fujii T; Furuichi Y; Furuuchi T; Sasano T; Imai E; Omae M; Yamada S; Watanuki M; Murakami S^*

来源：Journal of Dental Research, 2011, 90(1): 35-40.

DOI：10.1177/0022034510384616

• periodontitis
• tissue regeneration
• fibroblast growth factor-2

The efficacy of the local application of recombinant human fibroblast growth factor-2 (FGF-2) in periodontal regeneration has been investigated. In this study, a randomized, double-blind, placebo-controlled clinical trial was conducted in 253 adult patients with periodontitis. Modified Widman periodontal surgery was performed, during which 200 mu L of the investigational formulation containing 0% (vehicle alone), 0.2%, 0.3%, or 0.4% FGF-2 was administered to 2- or 3-walled vertical bone defects. Each dose of FGF-2 showed significant superiority over vehicle alone (p < 0.01) for the percentage of bone fill at 36 wks after administration, and the percentage peaked in the 0.3% FGF-2 group. No significant differences among groups were observed in clinical attachment regained, scoring approximately 2 mm. No clinical safety problems, including an abnormal increase in alveolar bone or ankylosis, were identified. These results strongly suggest that topical application of FGF-2 can be efficacious in the regeneration of human periodontal tissue that has been destroyed by periodontitis.

• 出版日期2011-1