Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study

作者：Dossus Laure; Franceschi Silvia; Biessy Carine; Navionis Anne-Sophie; Travis Ruth C.; Weiderpass Elisabete; Scalbert Augustin; Romieu Isabelle; Tjonneland Anne; Olsen Anja; Overvad Kim; Boutron-Ruault Marie-Christine; Bonnet Fabrice; Fournier Agnes; Fortner Renee T.; Kaaks Rudolf; Aleksandrova Krasimira; Trichopoulou Antonia; La Vecchia Carlo; Peppa Eleni; Tumino Rosario; Panico Salvatore; Palli Domenico; Agnoli Claudia; Vineis Paolo; Bueno-de-Mesquita H. B(as)

来源：International Journal of Cancer, 2018, 142(7): 1332-1342.

DOI：10.1002/ijc.31172

• thyroid cancer
• inflammation
• cytokine
• adipokine
• prospective cohort

Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-alpha and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1=0.69, 95% CI: 0.49-0.98, P-trend=0.04) but not among men (ORT3vs.T1=1.36, 95% CI: 0.67-2.76, P-trend=0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1=1.59, 95% CI: 1.13-2.25, P-trend=0.01) but not in men (ORT3vs.T1=1.78, 95% CI: 0.80-3.98, P-trend=0.17). Leptin, CRP, IL-6 and TNF-alpha were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.
What's new?
How does being overweight lead to thyroid cancer? These authors investigated, using data from the EPIC cohort. Considering obesity as a state of chronic inflammation, they looked at levels of various proteins associated with inflammation, including C-reactive protein, IL-10, adiponectin, and others, and compared these with TC risk. Women with high adiponectin levels were less likely to develop thyroid cancer, while those with high IL-10 levels had increased TC risk. No significant association was seen in men.

• 出版日期2018-4-1