摘要
A novel acetyl chloride-mediated cascade transformation involving three components ( benzyl carbamate, ethyl glyoxylate and arene nucleophiles) is reported. Aryl orthogonally protected alpha-amino acids are obtained in a one pot cascade, using a mild AcOH-AcCl system, via a critical autocatalytic dehydration-activation step ensuring an original and efficient Friedel-Crafts orchestration.
- 出版日期2014