New Anti-inflammatory 4-Hydroxyisoflavans from Solanum lyratum

作者:Zhang, De-Wu; Li, Gui-Hai; Yu, Qun-Ying; Dai, Sheng-Jun*
来源:Chemical & Pharmaceutical Bulletin, 2010, 58(6): 840-842.
DOI:10.1248/cpb.58.840

摘要

Three new 4-hydroxyisoflavans, named lyratin A (1), lyratin B (2) and lyratin C (3), along with a known compound, 4,7,2'trihydroxy-4'-methoxyisoflavan (4), were isolated from the whole plant of Solanum lyratum. Their structures were established by means of detailed physical data analyses. In vitro, four compounds showed anti-inflammatory activities with inhibitory ratios of release of beta-glucuronidase from polymorphonuclear leukocytes of rats in the range of 30.3-38.6% at 10 mu(M).

  • 出版日期2010-6
  • 单位烟台大学; 山东省中医药研究院