NF kappa B/p53 crosstalk-a promising new therapeutic target

作者：Schneider Guenter; Kraemer Oliver H

来源：Biochimica et Biophysica Acta-Reviews on Cancer, 2011, 1815(1): 90-103.

DOI：10.1016/j.bbcan.2010.10.003

• RelA/p65
• NF kappa B p53
• Signaling
• Therapy
• Cancer

The transcription factors p53 and NF kappa B determine cellular fate and are involved in the pathogenesis of most-if not all-cancers. The crosstalk between these transcription factors becomes increasingly appreciated as an important mechanism operative during all stages of tumorigenesis, metastasis, and immunological surveillance. In this review, we summarize molecular mechanisms regulating cross-signaling between p53 and NF kappa B proteins and how dysregulated interactions between p53 and NF kappa B family members contribute to oncogenesis. We furthermore analyze how such signaling modules represent targets for the design of novel intervention strategies using established compounds and powerful combination therapies.

• 出版日期2011-1