Adipokines, asymmetrical dimethylarginine, and pulmonary function in adolescents with asthma and obesity

作者：Huang Fengyang; Estela del Rio Navarro Blanca; Torres Alcantara Saul; Alfredo Perez Ontiveros Jose; Ruiz Bedolla Eliseo; Josue Saucedo Ramirez Omar; Villafana Santiago; Sanchez Munoz Fausto; Bravo Guadalupe; Hong Enrique

来源：Journal of Asthma, 2017, 54(2): 153-161.

DOI：10.1080/02770903.2016.1200611

• Adolescents
• asthma
• HMW adiponectin
• leptin
• obesity
• RBP4

Objective: This study was to investigate whether the metabolic abnormalities of adipokines and asymmetrical dimethylarginine (ADMA) associate with pulmonary function deficits in adolescentswith obesity and asthma. Methods: This study enrolled 28 obese adolescentswith asthma, 46 obese adolescents without asthma, 58 normal-weight adolescents with asthma, and 63 healthy control subjects. Serum levels of leptin, high-molecule-weight (HMW) adiponectin, retinol binding protein 4 (RBP4), asymmetrical dimethylarginine (ADMA), and pulmonary function were qualified. Results: The obese subjects had higher levels of leptin and ADMA but lower levels of HMW adiponectin than the normal-weight subjects with or without asthma. The subjects with asthma had higher levels of RBP4 than those without asthma. The obese adolescents with asthma had lowest forced expiratory lung volume in the first second (FEV1)/forced vital capacity (FVC) ratio among the four study groups. In all the study subjects and in the subjects with asthma alone, the FEV1/FVC ratio associated negatively with leptin, however, such associationwas rendered non-significant when adjusted for BMI. The pulmonary function deficits associated inversely with BMI percentile in the subjects with asthma. However, the decreased FEV1/FVC ratio was not correlated with HMW adiponectin, RBP4 or ADMA. Conclusions: Our present study confirmed obstructive pattern of pulmonary function characterized by the reduced FEV1/FVC ratio in the obese adolescentswith asthma. These pulmonary deficitswere associated inversely with the increased BMI percentile.

• 出版日期2017