A test of maternal human chorionic gonadotropin during pregnancy as an adaptive filter of human gestations

作者：Bruckner Tim A^*; Saxton Katherine B; Pearl Michelle; Currier Robert; Kharrazi Martin

来源：Proceedings of the Royal Society B, 2012, 279(1747): 4604-4610.

DOI：10.1098/rspb.2012.1797

• relaxed filter stringency
• human chorionic gonadotropin
• parity
• interbirth interval
• foetal loss

The risk of abnormalities and morbidity among live births increases with advanced maternal age. Explanations for this elevated morbidity invoke several maternal mechanisms. The relaxed filter stringency (RFS) hypothesis asserts that mothers, nearing the end of their reproductive lifespan, reduce the stringency of a screen of offspring quality in utero based on life-history traits of parity and interbirth interval (IBI). A separate line of research implicates human chorionic gonadotropin (hCG) during pregnancy as a signal of offspring quality. We test the RFS hypothesis directly by examining whether the difference in gestational hCG across consecutive live births varies positively with the mother's number of previous live births but inversely with her most recent IBI. We applied multivariable regression methods to a unique dataset of gestational hCG for over 500 000 live births from 2002 to 2007. The difference in gestational hCG across mothers' consecutive live births varies positively with both mothers' parity and IBI. These associations remain similar among older mothers (35+ years). Findings support the RFS hypothesis for the parity expectation but not for the IBI expectation. Further evidence for the RFS hypothesis among contemporary human gestations would have to invoke screening mechanisms other than hCG.

• 出版日期2012-11-22