A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach

作者：de Melo Monica Santos; Siqueira Quintans Jullyana de Souza; de Souza Araujo Adriano Antunes; Duarte Marcelo Cavalcante; Bonjardim Leonardo Rigoldi; de Lima Nogueira Paulo Cesar; de Souza Moraes Valeria Regina; de Araujo Junior Joao Xavier; Nogueira Ribeiro Eurica Adelia; Quintans Junior Lucindo Jose

来源：Evidence-Based Complementary and Alternative Medicine, 2014, 2014: 960258.

DOI：10.1155/2014/960258

Background. Clusiaceae family (sensu lato) is extensively used in ethnomedicine for treating a number of disease conditions which include cancer, inflammation, and infection. The aim of this review is to report the pharmacological potential of plants of Clusiaceae family with the anti-inflammatory activity in animal experiments. Methods. A systematic review about experiments investigating anti-inflammatory activity of Clusiaceae family was carried out by searching bibliographic databases such as Medline, Scopus and Embase. In this update, the search terms were "anti-inflammatory agents," " Clusiaceae," and "animals, laboratory." Results. A total of 255 publications with plants this family were identified. From the initial 255 studies, a total of 21 studies were selected for the final analysis. Studies with genera Allanblackia, Clusia, Garcinia or Rheedia, and Hypericum showed significant anti-inflammatory activity. The findings include a decrease of total leukocytes, a number of neutrophils, total protein concentration, granuloma formation, and paw or ear edema formation. Other interesting findings included decreased of the MPO activity, and inflammatory mediators such as NF-kappa B and iNOS expression, PGE(2) and Il-1 beta levels and a decrease in chronic inflammation. Conclusion. The data reported suggests the anti-inflammatory effect potential of Clusiaceae family in animal experiments.

• 出版日期2014