A Dimer to Bridge Early Autophagosomal Membranes

作者:Reggiori Fulvio*; Ungermann Christian
来源:Cell, 2012, 151(7): 1403-1405.
DOI:10.1016/j.cell.2012.12.008

摘要

The Atg1/ULK complex plays a key role in the early stages of autophagosome assembly. In this issue, Ragusa et al. reveal the molecular basis for some interactions within this complex, finding that the crescent-shaped Atg17 dimer is critical for autophagy, whereas Atg1 may have the ability to cluster membranes.

  • 出版日期2012-12-21