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摘要
A cell permeable fluorescence turn-on probe, AcGQCy7, was developed to image beta-galactosidase activity in living cells. Once internalized by beta-galactosidase-expressing cells, the probe was hydrolyzed into a highly fluorescent molecule, and the fluorescent signal was retained in mitochondria for several days. This resulted in a long-lasting and strong beta-galactosidase-dependent intracellular fluorescent signal with little background fluorescence in the culture media.
- 出版日期2013
