Association of Diabetes in Pregnancy with Child Weight at Birth, Age 12 Months and 5 Years - A Population-Based Electronic Cohort Study

作者：Morgan Kelly^*; Rahman Mohammed; Atkinson Mark; Zhou Shang Ming; Hill Rebecca; Khanom Ashrafunnesa; Paranjothy Shantini; Brophy Sinead

来源：PLos One, 2013, 8(11): e79803.

DOI：10.1371/journal.pone.0079803

Background: This study examines the effect of diabetes in pregnancy on offspring weight at birth and ages 1 and 5 years. %26lt;br%26gt;Methods: A population-based electronic cohort study using routinely collected linked healthcare data. Electronic medical records provided maternal diabetes status and offspring weight at birth and ages 1 and 5 years (n=147,773 mother child pairs). Logistic regression models were used to obtain odds ratios to describe the association between maternal diabetes status and offspring size, adjusted for maternal pre-pregnancy weight, age and smoking status. %26lt;br%26gt;Findings: We identified 1,250 (0.9%) pregnancies with existing diabetes (27.8% with type 1 diabetes), 1,358 with gestational diabetes (0.9%) and 635 (0.4%) who developed diabetes post-pregnancy. Children whose mothers had existing diabetes were less likely to be large at 12 months (OR: 0.7 (95%CI: 0.6, 0.8)) than those without diabetes. Maternal diabetes was associated with high weight at age 5 years in children whose mothers had a high pre-pregnancy weight tertile (gestational diabetes, (OR: 2.1 (95%CI:1.25-3.6)), existing diabetes (OR:1.3(95%CI:1.0 to 1.6)). %26lt;br%26gt;Conclusion: The prevention of childhood obesity should focus on mothers with diabetes with a high maternal pre-pregnancy weight. We found little evidence that diabetes in pregnancy leads to long term obesity %26apos;programming%26apos;.

• 出版日期2013-11-13