Divergent Synthesis of Imidazoles and Quinazolines via Pd(OAc)(2)-Catalyzed Annulation of N-Allylamidines

作者：Xu, Li; Li, Hongxian; Liao, Ziyang; Lou, Kaiyan; Xie, Hexin; Li, Hao; Wang, Wei

来源：Organic Letters, 2015, 17(14): 3434-3437.

DOI：10.1021/acs.orglett.5b01435

• ONE-POT SYNTHESIS
• 2-SUBSTITUTED QUINAZOLINES
• PROPARGYL AMIDINES
• DERIVATIVES
• 2-PHENYLQUINAZOLINES
• ACTIVATION
• MECHANISM
• ARYLATION
• REAGENTS
• BONDS

A Pd(OAc)(2)-catalyzed divergent synthesis of multisubstituted imidazoles and quinazolines from N-allylamidines has been developed. In the presence of oxidant O-2 from air and/or a ligand and Pd(OAc)(2) imidazoles were obtained. Nonetheless, under microwave (MW) irradiation in a sealed system, quinazolines as major products were produced.

• 出版日期2015-7-17
• 单位华东理工大学