科研之友
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摘要
Background: The aim of this study was to investigate the expression patterns of estrogen receptor (ER) beta 1 (wild-type ER beta) and ER beta 2 (ER beta cx) in papillary thyroid cancer (PTC) and nodular thyroid goiter (NTG), and to explore the reasons for the higher incidence of PTC in women of reproductive age. Material/Methods: ER beta 1 and ER beta 2 expression was examined immunohistochemically on paraffin-embedded thyroid tissues from 106 patients with PTC and 30 patients with NTG. Results: There was significant difference in the subcellular localization of ER beta 1 (P < 0.001), but not in the positive percentage, between PTC and NTG specimens. No significant difference was found in the positive percentage or the subcellular distribution of ER beta 2 expression between PTC and NTG specimens. Both nuclear and nucleocytoplasmic ER beta 1 expressions were significantly lower in PTC lesions than in NTG tissue (P < 0.001 and P < 0.05, respectively), while ER beta 2 expression was significantly higher in the former than the latter (P < 0.05). ER beta 1 expression in reproductive-aged (18 similar to 45 years) female patients with PTC was lower than that in age-matched male patients (P < 0.05), while ER beta 2 expression had the opposite expression profile (P < 0.05). There was no significant difference in ER beta 1 and ER beta 2 expression between reproductive-aged and advanced reproductive-aged (> 45 years) female patients with PTC. Conclusions: This preliminary study indicates that the expression patterns of ER beta 1 and ER beta 2 differ between malignant PTC lesions and benign NTG tissue, and their expression might be involved in the female predominance of PTC during the reproductive years. The clinical and biological significance of these results await further investigation.
- 出版日期2012-9
- 单位中国医科大学
