Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to psoriasis in a Chinese population

作者：Yang, KeDa; Zhang, Fan; Li, FangFang; Su, Juan; Wen, SaiLan; Liu, Yang; Feng, DeYun^*

来源：Journal of the Renin-Angiotensin-Aldosterone System, 2014, 15(1): 39-43.

DOI：10.1177/1470320313494433

• Psoriasis
• gene polymorphism
• angiotensin-converting enzyme

Introduction:
The relationship between the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and psoriasis has previously been studied mainly in Caucasians and only once in Asians. The aim of this study is to evaluate the association between the ACE I/D polymorphism and the risk of psoriasis in a Chinese population.
Materials and methods:
The study population consisted of 668 psoriasis patients and 668 matched control subjects. The ACE I/D gene polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results:
The frequency of the ACE II genotype (odds ratio (OR) = 1.32, 95% confidence interval (CI) = 1.06, 1.63; P = 0.01) and I allele (OR = 1.25, 95% CI = 1.06, 1.48; P = 0.01) in patients with psoriasis was significantly higher than that in the control group. And the D allele frequency in patients with psoriasis was significantly lower (OR = 0.80, 95% CI = 0.68, 0.95; P = 0.01) than that in the control group. When stratified by family history, the frequency of the DD genotype was marginally significantly lower in patients with a positive family history of psoriasis (familial psoriasis) than in those with negative (sporadic psoriasis) (OR = 0.47, 95% CI = 0.23, 0.97; P = 0.04). When stratified by onset of the disease, type of psoriasis and the severity of psoriasis, no statistically significant result was observed.
Conclusion:
Our study suggested that the ACE II genotype and I allele might confer susceptibility to psoriasis in a Chinese population.

• 出版日期2014-3
• 单位中南大学