科研之友
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摘要
Benzothiazole derivatives 1-22 were synthesized from 2-aminothiophenol and all synthetic compounds were screened for in vitro antileishmanial activity. These compound showed different types activities against leishmania with IC50 values ranging between 18.32 - 81.89 mu M. Compound 2 (IC50 = 18.32 +/- 0.18 mu M), 5 (IC50 = 19.72 +/- 0.32 mu M), and 3 (IC50 = 21.87 +/- 0.43 mu M)were found to be the most active compounds among the series when compared to the standard (Pentamidine, IC50 = 5.09 +/- 0.04 mu M). Compounds 7 and 11 exhibited weak activities, while compounds 5, 6, 7, 10, 11, and 16 were also found active. However, remaining compounds were found to be inactive against leishmania.
- 出版日期2015-2
