NEW METHOD FOR THE SYNTHESIS OF DIFFICULTLY AVAILABLE STERICALLY HINDERED TRITIUM-LABELED PYRIDINIUM DERIVATIVES

作者：Shchepina N E^*; Avrorin V V; Badun G A; Fedoseev V M; Lewis S B

来源：Chemistry of Heterocyclic Compounds, 2010, 46(5): 547-552.

DOI：10.1007/s10593-010-0544-8

• nucleogenic phenyl cations. N-phenyl-2,6-lutidinium and N-phenyl-2,4,6-collidinium salts
• tritium
• direct phenylation of pyridine nitrogen atom

Direct phenylation of the nitrogen atom in pyridines was noted in a study of the ion-molecule reactions of free nucleogenic phenyl cations generated by beta-decay of tritium in labeled benzene. A one-step synthesis of unreported biologically active tritium-labeled N-phenyl-2,6-lutidinium and 2,4,6-collidinium salts. Steric factors, which significantly reduce the yield in the case of sym-collidine, play a major role in the direct phenylation of nitrogen.

• 出版日期2010-9