A molecularly imprinted electrochemiluminescence sensor based on upconversion nanoparticles enhanced by electrodeposited rGO for selective and ultrasensitive detection of clenbuterol

作者：Jin, Xincui; Fang, Guozhen^*; Pan, Mingfei; Yang, Yukun; Bai, Xiaoyun; Wang, Shuo^*

来源：Biosensors and Bioelectronics, 2018, 102: 357-364.

DOI：10.1016/j.bios.2017.11.016

• Electrochemiluminescence sensor
• Reduced graphene oxide
• Upconversion nanopartides
• Molecularly imprinted polymers
• Clenbuterol

A simple, efficient and sensitive molecularly imprinted electrochemiluminescence sensor (MIECLS) based on reduced graphene oxide (rGO) and upconversion nanoparticles (UCNPs) was developed for determination of clenbuterol (CLB). In this study, rGO generated by electrodeposition of graphene oxide not only acted as carrier for immobilizing UCNPs, but also had a significant impact in boosting electrochemiluminescence (ECL) response of UCNPs thanks to its high conductivity, superior electron transport rate and large specific surface area. UCNPs as an advanced ECL emitter possessed wonderful ECL performance. Furthermore, the introduction of molecularly imprinted polymers (MIP) endowed the ECL sensor a new character of specifically identifying analyte CLB. Under the optimal experimental conditions, the ECL signal was proportional to the logarithm of CLB concentration in the range of 10 nM to 100 mu M with a low detection limit of 6.3 nM. The proposed MIECLS combining the advantages of UCNPs-ECL and MW exhibited good sensitivity, desirable selectivity and favorable stability, indicating enormous potential in the future of food safety detection.

• 出版日期2018-4-15
• 单位山西大学; 北京工商大学; 天津科技大学