Antibacterial and free radical scavenging potential of synthesized 7-hydroxy-2-aryl-6-aryldiazenyl-4H-chromen-4-ones

作者：Sharma Pawan Kumar; Bandyopadhyay Prabal; Sharma Pratibha; Kumar Ashok^*

来源：Medicinal Chemistry Research, 2014, 23(7): 3569-3584.

DOI：10.1007/s00044-014-0938-8

• Flavone
• Antibacterial activity
• Antioxidant activity
• DPPH radical scavenging method

A series of 7-hydroxy-2-aryl-6-aryldiazenyl-4H-chromen-4-one derivatives (6a-m) was synthesized in quantitative yields and their structures were corroborated on the basis of FT-IR, H-1, C-13 NMR, ESI-MS, and elemental analysis data. The synthesized compounds were screened for in vitro antibacterial activities against a representative panel of Gram-positive and Gram-negative bacteria, as well as to evaluate their antioxidant potential using DPPH assay method. Bio-evaluation studies revealed that compounds 6c, 6d, 6e, 6j, and 6l exhibited moderate to good antibacterial activity against all the tested bacterial strains. Furthermore, from the antioxidant screening results, it has been observed that compounds 6c, 6e, and 6g manifested profound antioxidant potential (IC50 < 7.68 mu M) in comparison to the standard antioxidant ascorbic acid.

• 出版日期2014-7