Detection of S100B in maternal blood before and after fetal death

作者：Beharier Ofer^*; Shusterman Eden; Eshcoli Tamar; Szaingurten Solodkin Irit; Aricha Tamir Barak; Weintraub Adi Y; Sheiner Eyal; Holcberg Gershon; Hershkovitz Reli

来源：Prenatal Diagnosis, 2014, 34(1): 94-97.

DOI：10.1002/pd.4266

BackgroundS100B is a brain damage biomarker. When measured immediately after birth, it reflects neonatal brain damage following asphyxia. In this study, we used feticide as a novel model of fetal brain damage. We examined whether such damage is reflected by a rise in S100B in maternal blood before delivery.
MethodsEight pregnant women were recruited between January and July 2012. Maternal blood samples were drawn before and after feticide at predetermined time points (0, 15, 30, 60, 120, and 240min). S100B, lactate dehydrogenase, creatine kinase, and creatinine concentrations were measured by standard human ELISA and chemical analyzer.
ResultsNo significant difference was noted between S100B levels before and after feticide, neither in non-specific cell death markers (lactate dehydrogenase and creatine kinase), which remained within normal range. S100B ranged between 0.015-0.04 mu g/L through all the predetermined time points.
ConclusionNo statistically significant differences were demonstrated in S100B levels before and after feticide.

• 出版日期2014-1