Aziridines in parallel- and solid-phase synthesis

作者:Olsen Christian A*; Franzyk Henrik; Jaroszewski Jerzy W
来源:European Journal of Organic Chemistry, 2007, 2007(11): 1717-1724.
DOI:10.1002/ejoc.200600837

摘要

Aziridines are versatile and powerful building blocks in organic synthesis due to their high reactivity as well as stereo- and regioselectivity of their ring-opening reactions with nucleophiles. Thus, aziridines possess potential as building blocks in the preparation of combinatorial. libraries for biological high-throughput screening. Although the development of strategies for parallel synthesis and solid-phase chemistry utilizing aziridines is still in its infancy, the diverse applications described so far emphasize their utility.

  • 出版日期2007-4