Hyalinizing Clear Cell Carcinoma with Biopsy-Proven Spinal Metastasis: Case Report and Review of Literature

作者：Newman William C; Williams Lindsay; Duvvuri Umamaheswar; Clump David A II; Amankulor Nduka^*

来源：World Neurosurgery, 2016, 90: UNSP 699.e7.

DOI：10.1016/j.wneu.2016.02.001

• EWSR1-ATF1
• Fluorescence in situ hybridization
• Histopathology
• Hyalinizing clear cell carcinoma
• Spine metastasis

BACKGROUND: Hyalinizing clear cell carcinoma (HCCC) is a rare epithelial malignant neoplasm typically arising from the minor salivary glands. Although it has been described as a benign neoplasm, there are increasing reports of malignant features and metastases to the lungs; we present the first case of biopsy-proven spinal metastases from HCCC and an overview of the literature.
CASE DESCRIPTION: This is a single-patient case report in which we used immunohistochemistry and fluorescence in situ hybridization for Ewing sarcoma breakpoint region 1 translocation to confirm the diagnosis of HCCC in a spinal metastasis. The diagnosis of metastatic HCCC was confirmed on the basis of histopathology, immunohistochemistry, and fluorescence in situ hybridization studies.
CONCLUSIONS: We present the first pathologically confirmed case of a spinal metastasis in HCCC. As increasing of metastatic HCCC arise, a reconsideration of HCCC as a potentially high-grade disease seems increasingly necessary as it may impact the current treatment paradigm.

• 出版日期2016-6