MRI compatible small animal monitoring and trigger system for whole body scanners

作者：Herrmann Karl Heinz^*; Pfeiffer Norman; Krumbein Ines; Herrmann Lutz; Reichenbach Juergen R

来源：Zeitschrift für Medizinische Physik, 2014, 24(1): 55-64.

DOI：10.1016/j.zemedi.2013.07.005

• Small animal imaging
• physiological monitoring
• MRI
• respiratory trigger
• motion suppression

Performing magnetic resonance imaging (MRI) experiments with small animals requires continuous monitoring of vital parameters, especially the respiration rate. Clinical whole-body MR scanners represent an attractive option for preclinical imaging as dedicated animal scanners are cost-intensive in both investment and maintenance, thus limiting their availability. Even though impressive image quality is achievable with clinical MR systems in combination with special coils, their built-in physiologic monitoring and triggering units are often not suited for small animal imaging. In this work, we present a simple, MRI compatible low cost solution to monitor the respiration and heart rate of small animals in a clinical whole-body MR scanner The recording and processing of the biosignals as well as the optimisation of the respiratory trigger generation is decri bed. Additionally rat and mouse in-vivo MRI experiments are presented to illustrate the effectiveness of the monitoring and respiratory trigger system in suppressing motion artifacts.

• 出版日期2014