A New Approach for the Synthesis of Hyperbranched N-Glycan Core Structures from Locust Bean Gum

作者：Kumar Ravi H V; Naruchi Kentaro; Miyoshi Risho; Hinou Hiroshi; Nishimura Shin Ichiro^*

来源：Organic Letters, 2013, 15(24): 6278-6281.

DOI：10.1021/ol403140h

A novel protocol for the synthesis of general N-glycan core structures was established by means of Man beta(1 -%26gt; 4)Man peracetate derived from a naturally abundant locust bean gum as a key starting material. Phenyl (2-O-benzy1-4,6-O-benzylidine-beta-D-mannopyranosyl)-(1 -%26gt; 4)-3,6-di-O-benzyl-2-azido-2-deoxy-1-thio-beta-D-glucopyranoside facilitated the synthesis of key intermediates leading to hyperbranched N-glycan core structures.

• 出版日期2013-12-20