科研之友
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摘要
Since their discovery, antibiotic have cured a large number of bacterial infections and improved human life expectancy. However, the use of antibiotics has also led inexorably to the progressive development of bacterial resistance. Among the strategies developed by bacteria to overcome the action of antibiotics, impermeability of the wall and especially active efflux of antibiotics contributed to the emergence of resistance. Efflux pumps are ubiquitous bacterial proteins that recognize in the first place physiological substrates. However, opportunistic antibiotic transport activity by these systems, combined with other resistance mechanisms are responsible for the selection of strains highly resistant to multiple antibiotics, resulting in therapeutic failures. Research data provided by the characterization and molecular modelization of bacterial efflux pumps has been used to define strategies which may lead to the development of new molecules able to inhibit these systems. Meanwhile, new methods for the routine detection of efflux pumps by hospital laboratories are needed to limit the development of high-level multidrug resistance.
- 出版日期2011-9
