Allergenic sesquiterpene lactones from cushion bush (Leucophyta brownii Cass.): new and old sensitizers in a shrub-turned-a-pot plant

作者：Paulsen Evy^*; Hyldgaard Mette G; Andersen Klaus E; Andersen Flemming; Christensen Lars P

来源：Contact Dermatitis, 2017, 76(5): 280-286.

DOI：10.1111/cod.12757

• Asteraceae
• calocephalin
• Compositae
• cushion bush: Leucophyta brownii
• leucophytalin A
• pseudoivalin
• tomentosin

Background. The Australian cushion bush (Leucophyta brownii) of the Compositae family of plants has become a popular pot and container plant. The plant produces the sesquiterpene lactone allergen calocephalin.
Objectives. To assess the sensitizing potential of sesquiterpene lactones from cushion bush.
Patients/Materials/Methods. Eleven Compositae-sensitive patients were patch tested with seven sesquiterpene lactones isolated from cushion bush.
Results. Six of seven sesquiterpene lactones elicited positive reactions in 4 of 11 patients.
Conclusions. The well-known sesquiterpene lactone pseudoivalin and its derivative pseudoivalin acetate, as well as calocephalin and tomentosin, were confirmed to be sensitizers, whereas leucophytalin A and 4 alpha.-hydroxy-5 alpha.H, 10 alpha H-1,11(13)-guaidien-8 beta,12-olide were shown to be allergenic for the first time. The patch test reaction patterns seem to follow the chemical patterns, which may eventually make it possible to trace primary sensitizers and advise patients more precisely.

• 出版日期2017-5