Aspirin and non-steroidal anti-inflammatory drugs use reduce gastric cancer risk: A dose-response meta-analysis

作者：Huang, Xuan-zhang; Chen, You; Wu, Jian; Zhang, Xi; Wu, Cong-cong; Zhang, Chao-ying; Sun, Shuang-shuang; Chen, Wen-jun^*

来源：Oncotarget, 2017, 8(3): 4781-4795.

DOI：10.18632/oncotarget.13591

• aspirin
• non-steroidal anti-inflammatory drugs
• gastric cancer
• chemoprevention
• meta-analysis

Background: The association between non-steroidal anti-inflammatory drugs (NSAIDs) and gastric cancer (GC) risk is controversial. The aim of this study is to evaluate the chemopreventive effect of NSAIDs for GC. @@@ Methods: A literature search was performed for relevant studies using the PubMed and Embase database (up to March 2016). Risk ratios (RRs) and 95% confidence intervals (CIs) were used as the effect measures. The dose-response analysis and subgroup analysis were also performed. @@@ Results: Twenty-four studies were included. Our results indicated that NSAIDs could reduce GC risk (any NSAIDs: RR = 0.78, 96% CI = 0.72-0.85; aspirin: RR = 0.70, 95% CI = 0.62-0.80; non-aspirin NSAIDs: RR = 0.86, 95% CI = 0.80-0.94), especially for non-cardia GC risk. Moreover, the dose-response analysis indicated the risk of GC decreased by 11% and 5% for 2 years increment of any NSAIDs and aspirin use, respectively. There were nonlinear relationships between the frequency of any NSAIDs use and aspirin use and GC risk (P for non-linearity < 0.01), with a threshold effect of 5 times/week. A monotonically decreasing trend was observed only for the frequency of less than 5 times/week. @@@ Conclusions: Our results indicate that NSAIDs is inversely associated with GC risk, especially for non-cardia GC risk. NSAIDs use may become a feasible approach to prevent GC.

• 出版日期2017-1-17
• 单位温州医科大学