Microbial carbonylation and hydroxylation of 20(R)-panaxadiol by Aspergillus niger

作者：Yan, Bin; Chen, Zhihua; Zhai, Xuguang; Yin, Guibo; Ai, Yafei; Chen, Guangtong^*

来源：Natural Product Research, 2018, 32(7): 782-787.

DOI：10.1080/14786419.2017.1360887

• Biotransformation
• 20(R)-panaxatriol
• Aspergillus niger
• anti-hepatic fibrosis

20(R)-panaxadiol (PD) was metabolised by the fungus Aspergillus niger AS 3.3926 to its C-3 carbonylated metabolite and five other hydroxylated metabolites (1-6). Their structures were elucidated as 3-oxo-20(R)-panaxadiol (1), 3-oxo-7 beta-hydroxyl-20(R)-panaxadiol (2), 3-oxo-7 beta, 23 alpha-dihydroxyl-20(R)-panaxadiol (3), 3,12-dioxo-7 beta, 23 beta-dihydroxyl-20(R)-panaxadiol (4), 3-oxo-1 alpha, 7 beta-dihydroxyl-20(R)panaxadiol (5) and 3-oxo-7 beta, 15 beta-dihydroxyl-20(R)-panaxadiol (6) by spectroscopic analysis. Among them, compounds 2-6 were new compounds. Pharmacological studies revealed that compound 6 exhibited significant anti-hepatic fibrosis activity. @@@ [GRAPHICS] @@@ .

• 出版日期2018
• 单位南通大学