科研之友
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摘要
A series of chiral phosphine-amine-oxazoline (PAO) ligands with an NH moiety were synthesized and applied to the ruthenium-catalyzed asymmetric hydrogenation of N-phosphinylimines. The ligand bearing phenyl groups at the phosphorus moiety and isopropyl at the oxazoline moiety exhibits good activity and excellent enantioselectivity (up to 99% ee). This catalytic system provides an efficient and mild approach to access enantioriched amines.
- 出版日期2018-12
- 单位中国科学院; 中国科学院大学; 金属有机化学国家重点实验室
