A randomized trial of memantine as treatment for spasticity in multiple sclerosis

作者：Mehta Lahar R^*; McDermott Michael P; Goodman Andrew D; Schwid Steven R

来源：Multiple Sclerosis, 2010, 16(2): 248-251.

DOI：10.1177/1352458509355462

• Ashworth scale
• memantine
• multiple sclerosis
• MSSS-88
• spasticity
• toe-tapping test

We report the results of a single center randomized, double-blind, placebo-controlled, parallel group trial of memantine in adults with multiple sclerosis and spasticity conducted over 12 weeks. Eligible MS patients had to have an Ashworth spasticity rating of 2 or higher in at least one lower extremity muscle group. Subjects were randomized to receive either placebo or memantine 10 mg twice a day. The primary outcome measure for efficacy was the change in Ashworth Spasticity Scale Score. Although well tolerated, memantine treatment did not demonstrate efficacy in treatment of spasticity in this 12-week small exploratory study.

• 出版日期2010-2