Forward vaccinology: CTL targeting based upon pnysical cetection of HLA-bound peptides

作者：Reinherz Ellis L^*; Keskin Derin B; Reinhold Bruce

来源：Frontiers in Immunology, 2014, 5: 418.

DOI：10.3389/fimmu.2014.00418

• T cell epitopes
• mass spectrometry
• vaccines
• proteomics
• CTL
• resident-memory T cells
• TCR

Vaccine-elicited cytotoxic T lymphocytes (CTL) recognizing conserved fragments of a pathogen's proteome could greatly impact infectious diseases and cancers. Enabling this potential are recent advances in mass spectrometry that identify specific target peptides among the myriad HLA-bound peptides on altered cells. Ultrasensitivity of these physical detection methods allows for the direct assessment of peptide presentation on small numbers of tissue-derived cells. In addition, concurrent advances in immunobiology suggest ways to induce CTLs with requisite functional avidity and tissue deployment. Elicitation of high-avidity resident-memory T cells through vaccination may shift the vaccinology paradigm both for preventive and therapeutic approaches to human disease control.

• 出版日期2014-9-4