New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis

作者:Yoshida Osamu; Nakamura Jun; Yamashiro Hidenori; Miura Kenji; Hayashi Sayaka; Umetsu Kosei; Xu Shu; Maki Hideki*; Arimoto Hirokazu
来源:Medchemcomm, 2011, 2(4): 278-282.
DOI:10.1039/c0md00230e

摘要

The emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. We previously reported vancomycin dimers with in vivo antibacterial activity. Here, we provide the first experimental insights into their inhibitory actions in bacterial cell wall synthesis.

  • 出版日期2011-4