Antiviral agents targeting glycans on dengue virus E-glycoprotein

作者：Hidari Kazuya I P J^*; Suzuki Takashi

来源：Expert Review of Anti-Infective Therapy, 2011, 9(11): 983-985.

DOI：10.1586/ERI.11.115

• carbohydrate-binding agent
• DC-SIGN
• dendritic cells
• dengue virus
• lectin

Evaluation of: Alen MMF, De Burghgraeve T, Kaptein SJF et al. Broad antiviral activity of carbohydrate-binding agents against the four serotypes of dengue virus in monocyte-derived dendritic cells. PLoS ONE 6(6), e21658 (2011).
The molecular recognition of dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) with arthropod-derived N-glycans on E-glycoprotein is essential for dengue virus (DENV) infection in humans. Therefore, the specific interaction of DC-SIGN with N-glycans on E-glycoprotein is a promising target for development of virus replication inhibitors. This article discusses the findings of a recent report describing antiviral activities of carbohydrate-binding agents, such as lectins and a small molecular weight compound against DENV infection of monocyte-derived dendritic cells. Several plant lectins and the small molecular weight compound Pladimicin-S showed potent inhibition of cellular infection by four DENV serotypes.

• 出版日期2011-11