Application of 2-chloro-4,6-dimethoxy-1,3,5-triazine in the synthesis of 2-azetidinones

作者：Shiraz Arnoosh Khademi; Zarei Maaroof^*

来源：Monatshefte fur Chemie, 2015, 146(6): 941-946.

DOI：10.1007/s00706-014-1354-y

• beta-Lactam
• 2-Azetidinone
• 2-Chloro-4,6-dimethoxy-1,3,5-triazine
• Staudinger reaction
• Schiff base

A novel and convenient method for the conversion of imines and carboxylic acids into beta-lactams using 2-chloro-4,6-dimethoxy-1,3,5-triazine at room temperature in dry dichloromethane is described. Optimization of the conditions was performed. This method is efficient and the water-soluble byproduct is removed by simple aqueous workup.

• 出版日期2015-6