Advanced atherosclerosis is associated with increased medial degeneration in sporadic ascending aortic aneurysms

作者：Albini Paul T; Segura Ana Maria; Liu Guanghui; Minard Charles G; Coselli Joseph S; Milewicz Dianna M; Shen Ying H; LeMaire Scott A^*

来源：Atherosclerosis, 2014, 232(2): 361-368.

DOI：10.1016/j.atherosclerosis.2013.10.035

• Aorta
• Thoracic aneurysm
• Atherosclerosis
• Muscle
• Smooth
• Elastin

Objective: The pathogenesis of non-familial, sporadic ascending aortic aneurysms (SAAA) is poorly understood, and the relationship between ascending aortic atherosclerosis and medial degeneration is unclear. We evaluated the prevalence and severity of aortic atherosclerosis and its association with medial degeneration in SAAA. %26lt;br%26gt;Methods and results: Atherosclerosis was characterized in ascending aortic tissues collected from 68 SAAA patients (mean age, 62.9 + 12.0 years) and 15 controls (mean age, 56.6 + 11.4 years [P = 0.07]) by using a modified American Heart Association classification system. Upon histologic examination, 97% of SAAA patients and 73% of controls showed atherosclerotic changes. Most SAAA samples had intermediate (types 2 and 3, 35%) or advanced atherosclerosis (types %26gt;= 4; 40%), whereas most control samples showed minimal atherosclerosis (none or type 1, 80%; P %26lt; 0.001 after adjusting for age). In a separate analysis, we examined the total incidence and grade distribution of medial degenerative changes among SAAA samples according to atherosclerosis grade. Advanced atherosclerosis was associated with higher grades of smooth muscle cell depletion (P %26lt; 0.001), elastic fiber depletion (P = 0.02), elastic fiber fragmentation (P %26lt; 0.001), and mucopolysaccharide accumulation (P = 0.04). Aortic diameter was larger in SAAA patients with advanced atherosclerosis than in patients with minimal (P 0.04) or intermediate atherosclerosis (P = 0.04). Immunostaining showed marked CD3+ T-cell and CD68+ macrophage infiltration, MMP-2 and MMP-9 production, and cryopyrin expression in the medial layer adjacent to atherosclerotic plaque. %26lt;br%26gt;Conclusions: SAAA tissues exhibited advanced atherosclerosis that was associated with severe medial degeneration and increased aortic diameter. Our findings suggest a role for atherosclerosis in the progression of sporadic ascending aortic aneurysms.

• 出版日期2014-2