Complete C-13-labeling pattern of yessotoxin a marine ladder-frame polyether

作者：Yamazaki Masatoshi; Tachibana Kazuo; Satake Masayuki^*

来源：Tetrahedron, 2011, 67(5): 877-880.

DOI：10.1016/j.tet.2010.12.015

• Biosynthesis
• Ladder-frame polyether
• C-13-Labeling
• Carbon deletion

Biosynthesis of a marine ladder-frame polyether yessotoxin (YTX) produced by the dinofalgellate Protoceratium reticulatum was investigated. The C-13-labeling experiments indicated that the carbons in YTX were derived from acetates, a methyl of methionine and glycolate, and six-membered ring tetrads (rings A-D and H-K) were constructed from repetition of C3 units (m-m-c), which consisted of a methyl of acetate and acetate.

• 出版日期2011-2-4